SOCS1 Antibody

Product description

Description

Order SOCS1 Antibody 01012614450 at Gentaur SOCS1

Price

320 EUR

Size

0,1 mg

Catalog no

PA1074

Details

Target antigen

SOCS1

Gene Name

SOCS1

Raised in

rabbit

Uniprot ID

O15524

Analyses

WB,IHC-P

French translation

anticorps

Product form

freeze-dried

Clone

Polyclonal antibody

Clonality

Polyclonal antibody

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Gene Full Name

suppressor of cytokine signaling 1

Reacts with species:

human, rat Predicted to work with: mouse

Protein Name

Suppressor of cytokine signaling 1(SOCS-1)

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS1(197-211aa NPVLRDYLSSFPFQI), identical to the related mouse and rat sequences.

Tips

The SOCS1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Storage condtions

Keep the SOCS1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Synonyms

CISH 1 antibody|CISH1 antibody|Cytokine Inducible SH2 Protein 1 antibody|JAB antibody|JAK Binding Protein antibody|JAK-binding protein antibody|Janus kinase binding protein antibody|SOCS 1 antibody|SOCS-1 antibody|Socs1 antibody|SOCS1_HUMAN antibody|SSI 1 antibody|SSI-1 antibody|SSI1 antibody|STAT Induced STAT Inhibitor 1 antibody|STAT-induced STAT inhibitor 1 antibody|Suppressor of cytokine signaling 1 antibody|Supressor of cytokine Signalling 1 antibody|TEC Interacting Protein 3 antibody|Tec-interacting protein 3 antibody|TIP 3 antibody|TIP-3 antibody|TIP3 antibody

Background

Suppressor of cytokine signaling 1(SOCS1), also known as Jak-binding protein(JAB), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.

Related articles

1. Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H.SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. J Biol Chem. 1997 Oct 24; 272(43):27178-82. 2. Kramer JA, Adams MD, Singh GB, Doggett NA, Krawetz SA.A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13. Somat Cell Mol Genet. 1998 Mar; 24(2):131-3. 3. Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, Kawanami O, Kishimoto T, Konishi N, Nakamura M, Kobayashi Y, Emi M.Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J Hum Genet. 2003; 48(2):65-9. 4. Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A.SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med. 2004 Jun 21; 199(12):1701-7.