Order anti-SOCS1 Antibody 01011888490 at Gentaur SOCS1
0.02 mg, 0.1 mg
Human, Mouse, Rat
ELISA, Western Blot
suppressor of cytokine signaling 1
SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.
SOCS1 Antibody is affinity chromatography purified via peptide column.
SOCS1 antibody can be used for the detection of SOCS1 by Western blot at 1 - 4 ug/mL.
SOCS1 antibody was made against a 15 amino acid synthetic peptide from near the carboxy terminus of human SOCS1.
SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
SOCS1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.