anti-SOCS1 Antibody

Product description

Description

Order anti-SOCS1 Antibody 01011888491 at Gentaur SOCS1

Price

180 EUR

Size

0.02 mg, 0.1 mg

Catalog no

3767

Details

Immunoglobulin

IgG

NCBI GENE nr

8651

Works with

Human

GENE symbol

SOCS1

Ab raised in

Rabbit

Protein nr

O15524

Omim nr

8217331

Quantity per ml

1 mg/mL

Ncbi nr

CAB92528

French translation

anticorps

Type

Polyclonal

Vial with antibody

in solution

Source

Homo sapiens

Antibodie's label

unlabelled serum

Immuno application

ELISA, Western Blot

Antigene name

suppressor of cytokine signaling 1

Suspention, pH, azide

SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.

Purity

SOCS1 Antibody is affinity chromatography purified via peptide column.

Antibody advice

SOCS1 antibody can be used for the detection of SOCS1 by Western blot at 1 - 4 ug/mL.

Antigen

SOCS1 antibody was made against a 17 amino acid synthetic peptide from near the amino terminus of human SOCS1.

Gene names

SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Keep at

SOCS1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Gene info

SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.