Order anti-SOCS1 Antibody 01012193017 at Gentaur SOCS1
Shelf time: 12 months in temp.: -20 deg.C
The antibody solution should be gently mixed before use.
Synthetic peptide surrounding amino acid 196 of rat SOCS1
CIS1 ,CISH1 , JAB , JAK binding protein , SOCS-1 , SOCS1 ,SSI-1 , SSI1 , TIP3
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~30 kDa SOCS1 on SDS-PAGE immunoblots. Blocking peptide (Cat.# 3861BP-50) is available separately.
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate responses to cytokines. SOCS1 suppresses dendritic cell and T cell hyperactivation in response to cytokine signaling by inhibiting the JAK tyrosine kinase. JAK tyrosine kinase activity is important for type I and II cytokine receptors to initiate signaling, and its activity is inhibited by direct binding of SOCS1 to the catalytic domain of the kinase. SOCS1 also has E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.